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ALT/AST Ratio Formula:
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The ALT/AST ratio is a calculation used in hepatology to help differentiate between various liver conditions. ALT (alanine aminotransferase) and AST (aspartate aminotransferase) are enzymes found in liver cells, and their ratio can provide insights into liver health and potential diseases.
The calculator uses a simple formula:
Where:
Explanation: The ratio compares the levels of these two liver enzymes, which can help clinicians distinguish between different types of liver injury.
Details: The ALT/AST ratio is particularly useful in distinguishing alcoholic liver disease (typically ratio < 1) from non-alcoholic liver diseases (typically ratio > 1). It can also provide clues about viral hepatitis, drug-induced liver injury, and other hepatic conditions.
Tips: Enter both ALT and AST values in U/L. Both values must be greater than zero for accurate calculation. Use recent laboratory results for the most accurate assessment.
Q1: What is a normal ALT/AST ratio?
A: A normal ALT/AST ratio is typically around 1.0-1.5, but this can vary based on individual factors and laboratory reference ranges.
Q2: What does a ratio less than 1 indicate?
A: A ratio less than 1 often suggests alcoholic liver disease, as AST tends to be higher than ALT in this condition.
Q3: What does a ratio greater than 2 indicate?
A: A ratio greater than 2 is often seen in acute viral hepatitis and may indicate more significant hepatocellular damage.
Q4: Are there limitations to this ratio?
A: Yes, the ratio should be interpreted in clinical context alongside other liver function tests, imaging studies, and patient history.
Q5: Can medications affect the ALT/AST ratio?
A: Yes, certain medications can affect liver enzyme levels and thus alter the ratio. Always consider medication history when interpreting results.