1. What is AST to ALT Ratio?

The AST to ALT ratio is a calculation used in hepatology to help differentiate between various liver diseases. It compares the levels of two liver enzymes: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the blood.

2. How Does the Calculator Work?

The calculator uses a simple formula:

Where:

• \( AST \) — Aspartate aminotransferase level (U/L)
• \( ALT \) — Alanine aminotransferase level (U/L)

Explanation: The ratio is calculated by dividing the AST value by the ALT value. This simple calculation can provide valuable clinical information about liver health.

3. Clinical Significance of AST/ALT Ratio

Details: The AST/ALT ratio can help differentiate between various liver conditions. A ratio greater than 2:1 is often associated with alcoholic liver disease, while a ratio less than 1:1 is more typical of viral hepatitis. However, this should always be interpreted in the context of other clinical findings.

4. Using the Calculator

Tips: Enter both AST and ALT values in U/L. Both values must be greater than zero for the calculation to be performed.

5. Frequently Asked Questions (FAQ)

Q1: What are normal AST and ALT levels?
A: Normal AST levels are typically 8-48 U/L, and normal ALT levels are 7-55 U/L, though reference ranges may vary by laboratory.

Q2: When is the AST/ALT ratio most useful?
A: The ratio is particularly useful in distinguishing alcoholic liver disease (ratio >2) from other forms of liver injury.

Q3: Can the AST/ALT ratio diagnose liver disease alone?
A: No, the ratio should be interpreted alongside other clinical findings, imaging studies, and laboratory tests for accurate diagnosis.

Q4: What does a ratio less than 1 indicate?
A: A ratio less than 1 is often seen in acute viral hepatitis and may indicate predominant ALT elevation.

Q5: Are there limitations to using this ratio?
A: Yes, the ratio should be used cautiously as many factors can affect AST and ALT levels, and it's not specific for any single condition.